Molecular markers of glioma initiating cells
نویسندگان
چکیده
منابع مشابه
Glioma - initiating Cells Retain
Background: Glioma-initiating cells are underlying causes of development and progression of glioblastoma. Results: Depletion of Oct4 expression suppresses tumorigenic activity of glioma-initiating cells through down-regulation of Sox2. Conclusion: Oct4 maintains tumorigenicity of glioma-initiating cells in cooperation with the Sox axis. Significance: This study uncovers transcriptional network ...
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tumor-initiating cells with stem cell properties are believed to sustain the growth of gliomas, but proposed markers such as Cd133 cannot be used to identify these cells with sufficient specificity. We report an alternative isolation method purely based on phenotypic qualities of glioma-initiating cells (GICs), avoiding the use of molecular markers. We exploited intrinsic autofluorescence prope...
متن کاملGlioma biology and molecular markers.
The tumors classified as gliomas include a wide variety of histologies including the more common (astrocytoma, glioblastoma), as well as the less common histologies (oligodendroglioma, mixed oligoastrocytoma, pilocytic astrocytoma). Recent efforts at comprehensive genetic characterization of various primary brain tumor types have identified a number of common alterations and pathways common to ...
متن کاملGlioma-associated cancer-initiating cells induce immunosuppression.
PURPOSE Glioblastoma multiforme is a lethal cancer that responds poorly to therapy. Glioblastoma multiforme cancer-initiating cells have been shown to mediate resistance to both chemotherapy and radiation; however, it is unknown to what extent these cells contribute to the profound immunosuppression in glioblastoma multiforme patients and if strategies that alter their differentiation state can...
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Glioma‑initiating cells are a small population of cells that have the ability to undergo self‑renewal and initiate tumorigenesis. In the present study, the potential role of salinomycin, a polyether antibiotic, on the suppression of glioma cell growth was investigated. GL261 glioma cells were maintained in a stem‑cell‑like status [GL261 neurospheres (GL261‑NS)] or induced for differentiation [G...
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ژورنال
عنوان ژورنال: Inflammation and Regeneration
سال: 2013
ISSN: 1880-9693,1880-8190
DOI: 10.2492/inflammregen.33.181